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Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples

INTRODUCTION: The thrombin generation (TG) test is a global hemostasis assay sensitive to procoagulant conditions. However, some TG assays may underestimate elevated TG when the thrombin fluorogenic substrate is depleted or fluorescence is attenuated by the inner filter effect (IFE). OBJECTIVES: We...

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Bibliographic Details
Published in:Res Pract Thromb Haemost
Main Authors: Chang, William C., Jackson, Joseph W., Machlus, Kellie R., Wolberg, Alisa S., Ovanesov, Mikhail V.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035796/
https://ncbi.nlm.nih.gov/pubmed/33870030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12499
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