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Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice

Studies have correlated elevated plasma factor VIII (FVIII) with thrombosis; however, it is unclear whether elevated FVIII is a proinflammatory biomarker, causative agent, or both. We raised FVIII levels in mice and measured the time to vessel occlusion (TTO) after ferric chloride–induced injury. Co...

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Bibliografiska uppgifter
Huvudupphovsmän: Machlus, Kellie R., Lin, Feng-Chang, Wolberg, Alisa S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3193271/
https://ncbi.nlm.nih.gov/pubmed/21828144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-362814
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