Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents

The androgen receptor inhibitor, Enzalutamide, proved effective against castration resistance prostate cancer, has demonstrated clinical benefits and increased survival rate in men. However, AR mutation (F876L) converts Enzalutamide from antagonist to agonist indicating a rapid evolution of resistan...

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Detalhes bibliográficos
Publicado no:Heliyon
Main Authors: Bhole, Ritesh P., Chikhale, Rupesh V., Wavhale, Ravindra D., Asmary, Fatmah Ali, Almutairi, Tahani Mazyad, Alhajri, Hassna Mohammed, Bonde, Chandrakant G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035491/
https://ncbi.nlm.nih.gov/pubmed/33869816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2021.e06227
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