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Design and synthesis of novel oridonin analogues as potent anticancer agents

To identify anticancer agents with higher potency and lower toxicity, a series of oridonin derivatives with substituted benzene moieties at the C17 position were designed, synthesised, and evaluated for their antiproliferative properties. Most of the derivatives exhibited antiproliferative effects a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Shen, Qing-Kun, Chen, Zheng-Ai, Zhang, Hong-Jian, Li, Jia-Li, Liu, Chuan-Feng, Gong, Guo-Hua, Quan, Zhe-Shan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054517/
https://ncbi.nlm.nih.gov/pubmed/29303372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1419219
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