Design of potential vitamin-drug conjugate for enhanced anticancer activity

5-Fluorouracil, a primary molecule widely used in the treatment of various cancer stages, is rapidly metabolized to an inactive form, namely 5,6-dihydro-5-FU and various mutational changes in chemotherapy. We utilized a carbodiimide catalyst to form a conjugate with folic acid. As folic acid recepto...

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Autors principals: R.P. Bhole, M.R. Swamy, R. Wavhale, C.G. Bonde, R. Chikhale
Format: Artigo
Idioma:Inglês
Publicat: Academician Ye.A. Buketov Karaganda University 2022-03-01
Col·lecció:Қарағанды университетінің хабаршысы. Химия сериясы
Matèries:
5-fluorouracil
folic acid
synthetic conjugate
molecular docking
molecular dynamics
drug de- sign
chemotherapeutic agent
human thymidylate synthase
Accés en línia:https://chemistry-vestnik.ksu.kz/apart/2022-105-1/01.pdf
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