SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2

Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate that the transcription factor SOX4 is a key regulator of PI3K...

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Publicado no:NPJ Breast Cancer
Main Authors: Mehta, Gaurav A., Angus, Steven P., Khella, Christen A., Tong, Kevin, Khanna, Pooja, Dixon, Shelley A. H., Verzi, Michael P., Johnson, Gary L., Gatza, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035213/
https://ncbi.nlm.nih.gov/pubmed/33837205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-021-00248-2
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