PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury

Because of the key role of impaired mitochondria in the progression of acute kidney injury (AKI), it is striking that peroxisome proliferator γ coactivator 1-α (PGC-1α), a transcriptional coactivator of genes involved in mitochondrial biogenesis and autophagy, protects from kidney injury. However, t...

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Publicado en:Aging (Albany NY)
Autores principales: Yuan, Longhui, Yuan, Yujia, Liu, Fei, Li, Lan, Liu, Jingping, Chen, Younan, Cheng, Jingqiu, Lu, Yanrong
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals 2021
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034953/
https://ncbi.nlm.nih.gov/pubmed/33714196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.202653
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