Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear. In this study, we aimed to investigate the spe...

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Publicat a:Theranostics
Autors principals: Zhao, Meng, Wang, Yizhuo, Li, Ling, Liu, Shuyun, Wang, Chengshi, Yuan, Yujia, Yang, Guang, Chen, Younan, Cheng, Jingqiu, Lu, Yanrong, Liu, Jingping
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2021
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778599/
https://ncbi.nlm.nih.gov/pubmed/33408785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.50905
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