Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear. In this study, we aimed to investigate the spe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Theranostics
Main Authors: Zhao, Meng, Wang, Yizhuo, Li, Ling, Liu, Shuyun, Wang, Chengshi, Yuan, Yujia, Yang, Guang, Chen, Younan, Cheng, Jingqiu, Lu, Yanrong, Liu, Jingping
Format: Artigo
Jezik:Inglês
Izdano: Ivyspring International Publisher 2021
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778599/
https://ncbi.nlm.nih.gov/pubmed/33408785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.50905
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