Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation, but the potential link among these features remains unclear. In this study, we aimed to investigate the spe...

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發表在:Theranostics
Main Authors: Zhao, Meng, Wang, Yizhuo, Li, Ling, Liu, Shuyun, Wang, Chengshi, Yuan, Yujia, Yang, Guang, Chen, Younan, Cheng, Jingqiu, Lu, Yanrong, Liu, Jingping
格式: Artigo
語言:Inglês
出版: Ivyspring International Publisher 2021
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7778599/
https://ncbi.nlm.nih.gov/pubmed/33408785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.50905
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