Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Targeting the metastatic process to prevent disease dissemination in cancer remains challenging. One step in the metastatic cascade involves cancer cells transiting through the vascular endothelium after inflammation has increased the permeability of this cellular layer. Reducing inflammation-mediat...

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Udgivet i:Cancer Lett
Main Authors: Chen, Yu-Chi, Dinavahi, Saketh S., Feng, Qilong, Gowda, Raghavendra, Ramisetti, Srinivasa, Xia, Xinghai, LaPenna, Kyle B, Chirasani, Venkat R., Cho, Sung Hyun, Hafenstein, Susan L., Battu, Madhu Babu, Berg, Arthur, Sharma, Arun K., Kirchhausen, Tom, Dokholyan, Nikolay V., Amin, Shantu, He, Pingnian, Robertson, Gavin P.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034284/
https://ncbi.nlm.nih.gov/pubmed/33600895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.01.004
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