Lipophilicity Determines Routes of Uptake and Clearance, and Toxicity of an Alpha-Particle-Emitting Peptide Receptor Radiotherapy

[Image: see text] Lipophilicity is explored in the biodistribution (BD), pharmacokinetics (PK), radiation dosimetry (RD), and toxicity of an internally administered targeted alpha-particle therapy (TAT) under development for the treatment of metastatic melanoma. The TAT conjugate is comprised of the...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Tafreshi, Narges K., Kil, HyunJoo, Pandya, Darpan N., Tichacek, Christopher J., Doligalski, Michael L., Budzevich, Mikalai M., Delva, Nella C., Langsen, Michael L., Vallas, John A., Boulware, David C., Engelman, Robert W., Gage, Kenneth L., Moros, Eduardo G., Wadas, Thaddeus J, McLaughlin, Mark L., Morse, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033749/
https://ncbi.nlm.nih.gov/pubmed/33860213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00035
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