Lipophilicity Determines Routes of Uptake and Clearance, and Toxicity of an Alpha-Particle-Emitting Peptide Receptor Radiotherapy

[Image: see text] Lipophilicity is explored in the biodistribution (BD), pharmacokinetics (PK), radiation dosimetry (RD), and toxicity of an internally administered targeted alpha-particle therapy (TAT) under development for the treatment of metastatic melanoma. The TAT conjugate is comprised of the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACS Pharmacol Transl Sci
Hauptverfasser: Tafreshi, Narges K., Kil, HyunJoo, Pandya, Darpan N., Tichacek, Christopher J., Doligalski, Michael L., Budzevich, Mikalai M., Delva, Nella C., Langsen, Michael L., Vallas, John A., Boulware, David C., Engelman, Robert W., Gage, Kenneth L., Moros, Eduardo G., Wadas, Thaddeus J, McLaughlin, Mark L., Morse, David L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033749/
https://ncbi.nlm.nih.gov/pubmed/33860213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00035
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge