Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

BACKGROUND: The receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) is a poor prognostic factor; however, the prognostic significance of missense mutation in the tyrosine kinase domain (FLT3-TKD) is controversial. Furthermore, the accompanying m...

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Bibliografiske detaljer
Udgivet i:Exp Hematol Oncol
Main Authors: Guan, Wei, Zhou, Lei, Li, Yan, Yang, Erna, Liu, Yangyang, Lv, Na, Fu, Lin, Ding, Yi, Wang, Nan, Fang, Nan, Liu, Qian, Wang, Binan, Li, Fuwei, Zhang, Juan, Wang, Maoquan, Wang, Lili, Jing, Yu, Li, Yonghui, Yu, Li
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033687/
https://ncbi.nlm.nih.gov/pubmed/33836835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-021-00207-4
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