A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors

BACKGROUND: Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1 subtype B isolates, elicited sub-optimal efficacy in clinical trials due to po...

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Gepubliceerd in:Retrovirology
Hoofdauteurs: Ghimire, Dibya, KC, Yuvraj, Timilsina, Uddhav, Goel, Kriti, Nitz, T. J., Wild, Carl T., Gaur, Ritu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2021
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033686/
https://ncbi.nlm.nih.gov/pubmed/33836787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-021-00553-5
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