Resistance to Second-Generation HIV-1 Maturation Inhibitors

A betulinic acid-based compound, bevirimat (BVM), inhibits HIV-1 maturation by blocking a late step in protease-mediated Gag processing: the cleavage of the capsid-spacer peptide 1 (CA-SP1) intermediate to mature CA. Previous studies showed that mutations conferring resistance to BVM cluster around...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Urano, Emiko, Timilsina, Uddhav, Kaplan, Justin A., Ablan, Sherimay, Ghimire, Dibya, Pham, Phuong, Kuruppu, Nishani, Mandt, Rebecca, Durell, Stewart R., Nitz, Theodore J., Martin, David E., Wild, Carl T., Gaur, Ritu, Freed, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401422/
https://ncbi.nlm.nih.gov/pubmed/30567982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02017-18
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