Resistance to Second-Generation HIV-1 Maturation Inhibitors

A betulinic acid-based compound, bevirimat (BVM), inhibits HIV-1 maturation by blocking a late step in protease-mediated Gag processing: the cleavage of the capsid-spacer peptide 1 (CA-SP1) intermediate to mature CA. Previous studies showed that mutations conferring resistance to BVM cluster around...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Urano, Emiko, Timilsina, Uddhav, Kaplan, Justin A., Ablan, Sherimay, Ghimire, Dibya, Pham, Phuong, Kuruppu, Nishani, Mandt, Rebecca, Durell, Stewart R., Nitz, Theodore J., Martin, David E., Wild, Carl T., Gaur, Ritu, Freed, Eric O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2019
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401422/
https://ncbi.nlm.nih.gov/pubmed/30567982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02017-18
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