Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer

Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell-extrinsic role of KRAS, where KRAS engages with the tumor microenvironment by functional reprogramming of tumor-associated...

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Vydáno v:Signal Transduct Target Ther
Hlavní autoři: Liu, Huashan, Liang, Zhenxing, Zhou, Chi, Zeng, Ziwei, Wang, Fengwei, Hu, Tuo, He, Xiaowen, Wu, Xiaojian, Wu, Xianrui, Lan, Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032794/
https://ncbi.nlm.nih.gov/pubmed/33833221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00534-2
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