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Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer
Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell-extrinsic role of KRAS, where KRAS engages with the tumor microenvironment by functional reprogramming of tumor-associated...
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| Publicado no: | Signal Transduct Target Ther |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8032794/ https://ncbi.nlm.nih.gov/pubmed/33833221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00534-2 |
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