Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction

Mitochondrial diseases impair oxidative phosphorylation and ATP production, while effective treatment is still lacking. Defective complex III is associated with a highly variable clinical spectrum. We show that pyocyanin, a bacterial redox cycler, can replace the redox functions of complex III, acti...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Peruzzo, Roberta, Corrà, Samantha, Costa, Roberto, Brischigliaro, Michele, Varanita, Tatiana, Biasutto, Lucia, Rampazzo, Chiara, Ghezzi, Daniele, Leanza, Luigi, Zoratti, Mario, Zeviani, Massimo, De Pittà, Cristiano, Viscomi, Carlo, Costa, Rodolfo, Szabò, Ildikò
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032734/
https://ncbi.nlm.nih.gov/pubmed/33833234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22062-x
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