Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

The redox activity of cytochrome c oxidase (COX), the terminal oxidase of the mitochondrial respiratory chain (MRC), depends on the incorporation of iron and copper into its catalytic centers. Many mitochondrial proteins have specific roles for the synthesis and delivery of metal-containing cofactor...

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Detalhes bibliográficos
Main Authors: Michele Brischigliaro, Denis Badocco, Rodolfo Costa, Carlo Viscomi, Massimo Zeviani, Paolo Pastore, Erika Fernández-Vizarra
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
mitochondrial respiratory chain
cytochrome c oxidase
copper
iron
zinc
manganese
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2022.892069/full
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