Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster

Cytochrome c oxidase (COX) deficiency is the biochemical hallmark of several mitochondrial disorders, including subjects affected by mutations in apoptogenic-1 (APOPT1), recently renamed as COA8 (HGNC:20492). Loss-of-function mutations are responsible for a specific infantile or childhood-onset mito...

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Bibliographische Detailangaben
Veröffentlicht in:Front Physiol
Hauptverfasser: Brischigliaro, Michele, Corrà, Samantha, Tregnago, Claudia, Fernandez-Vizarra, Erika, Zeviani, Massimo, Costa, Rodolfo, De Pittà, Cristiano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6742693/
https://ncbi.nlm.nih.gov/pubmed/31555154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01143
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