The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants

DNA replication inhibitors are utilized extensively in studies of molecular biology and as chemotherapy agents in clinical settings. The inhibition of DNA replication often triggers double-stranded DNA breaks (DSBs) at stalled DNA replication sites, resulting in cytotoxicity. In East Asia, some trad...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Inoue, Naomi, Terabayashi, Takeshi, Takiguchi-Kawashima, Yuri, Fujinami, Daisuke, Matsuoka, Shigeru, Kawano, Masanori, Tanaka, Kazuhiro, Tsumura, Hiroshi, Ishizaki, Toshimasa, Narahara, Hisashi, Kohda, Daisuke, Nishida, Yoshihiro, Hanada, Katsuhiro
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032691/
https://ncbi.nlm.nih.gov/pubmed/33833336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87344-2
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