RNA ImmunoGenic Assay: A Method to Detect Immunogenicity of in vitro Transcribed mRNA in Human Whole Blood

The mRNA therapeutics is a new class of medicine to treat many various diseases. However, in vitro transcribed (IVT) mRNA triggers immune responses due to recognition by human endosomal and cytoplasmic RNA sensors, but incorporation of modified nucleosides have been shown to reduce such responses. T...

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Bibliografske podrobnosti
izdano v:Bio Protoc
Main Authors: Haque, AKM Ashiqul, Weinmann, Petra, Biswas, Sumit, Handgretinger, Rupert, Mezger, Markus, Kormann, Michael S. D., Antony, Justin S
Format: Artigo
Jezik:Inglês
Izdano: Bio-Protocol 2020
Teme:
Methods Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032499/
https://ncbi.nlm.nih.gov/pubmed/33855105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.3850
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