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Modified mRNA as a new therapeutic option for pediatric respiratory diseases and hemoglobinopathies

BACKGROUND: The immunogenicity and limited stability of conventional messenger RNA (mRNA) has traditionally restricted its potential therapeutic use. In 1992, the first clinical application of mRNA was reported as a potential protein-replacement therapy; however, subsequent investigations have not b...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cell Pediatr
Hauptverfasser: Antony, Justin S., Dewerth, Alexander, Haque, Ashiqul, Handgretinger, Rupert, Kormann, Michael S.D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654728/
https://ncbi.nlm.nih.gov/pubmed/26589812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40348-015-0022-6
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