Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity

Cystic Fibrosis (CF) is the most common monogenic disease among people of Western European descent and caused by mutations in the CFTR gene. However, the disease severity is immensely variable even among patients with similar CFTR mutations due to the possible effect of ‘modifier genes’. To identify...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kormann, Michael S. D., Dewerth, Alexander, Eichner, Felizitas, Baskaran, Praveen, Hector, Andreas, Regamey, Nicolas, Hartl, Dominik, Handgretinger, Rupert, Antony, Justin S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573219/
https://ncbi.nlm.nih.gov/pubmed/28846703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183526
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