Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [(11)C]PBR28 in Elderly Individuals Without Dementia

OBJECTIVE: To examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia. METHODS: We examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tra...

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Pubblicato in:Neurology
Autori principali: Toppala, Sini, Ekblad, Laura L., Tuisku, Jouni, Helin, Semi, Johansson, Jarkko J., Laine, Hanna, Löyttyniemi, Eliisa, Marjamäki, Päivi, Blennow, Kaj, Zetterberg, Henrik, Jula, Antti, Viitanen, Matti, Rinne, Juha O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032368/
https://ncbi.nlm.nih.gov/pubmed/33514647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000011612
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