Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis

DEFA1A3 encodes human neutrophil peptides (HNPs) 1–3 and has multiple copy number variations (CNVs). HNPs are associated with innate immunity. Ulcerative colitis (UC), a chronic inflammatory gastrointestinal disorder, is a life-threatening condition, and predictive markers of UC severity are needed....

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Vydáno v:Clin Transl Gastroenterol
Hlavní autoři: Kanmura, Shuji, Morinaga, Yuko, Tanaka, Akihito, Komaki, Yuga, Iwaya, Hiromichi, Kumagai, Kotaro, Mawatari, Seiichi, Sasaki, Fumisato, Tanoue, Shiroh, Hashimoto, Shinichi, Sameshima, Yoichi, Ono, Yohei, Ohi, Hidehisa, Ido, Akio
Médium: Artigo
Jazyk:Inglês
Vydáno: Wolters Kluwer 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032364/
https://ncbi.nlm.nih.gov/pubmed/33825720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14309/ctg.0000000000000331
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