Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing

BACKGROUND: TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the TTN transcript are the most frequent cause of hereditary heart failure. We showed before that TTN produce...

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Bibliographic Details
Published in:Circulation
Main Authors: Tijsen, Anke J., Cócera Ortega, Lucía, Reckman, Yolan J., Zhang, Xiaolei, van der Made, Ingeborg, Aufiero, Simona, Li, Jiuru, Kamps, Selina C., van den Bout, Anouk, Devalla, Harsha D., van Spaendonck-Zwarts, Karin Y., Engelhardt, Stefan, Gepstein, Lior, Ware, James S., Pinto, Yigal M.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2021
Subjects:
Original Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032209/
https://ncbi.nlm.nih.gov/pubmed/33583186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.050455
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