Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing

BACKGROUND: TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the TTN transcript are the most frequent cause of hereditary heart failure. We showed before that TTN produce...

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Detalles Bibliográficos
Publicado en:Circulation
Main Authors: Tijsen, Anke J., Cócera Ortega, Lucía, Reckman, Yolan J., Zhang, Xiaolei, van der Made, Ingeborg, Aufiero, Simona, Li, Jiuru, Kamps, Selina C., van den Bout, Anouk, Devalla, Harsha D., van Spaendonck-Zwarts, Karin Y., Engelhardt, Stefan, Gepstein, Lior, Ware, James S., Pinto, Yigal M.
Formato: Artigo
Idioma:Inglês
Publicado: Lippincott Williams & Wilkins 2021
Assuntos:
Original Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032209/
https://ncbi.nlm.nih.gov/pubmed/33583186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.050455
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