CARD8 is an inflammasome sensor for HIV-1 protease activity

HIV-1 has high mutation rates and exists as mutant swarms within the host. Rapid evolution of HIV-1 allows the virus to outpace the host immune system, leading to viral persistence. Approaches to target immutable components are needed to clear HIV-1 infection. Here, we report that the CARD8 inflamma...

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Publicado no:Science
Main Authors: Wang, Qiankun, Gao, Hongbo, Clark, Kolin M., Mugisha, Christian Shema, Davis, Keanu, Tang, Jack P., Harlan, Gray H., DeSelm, Carl J., Presti, Rachel M., Kutluay, Sebla B., Shan, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8029496/
https://ncbi.nlm.nih.gov/pubmed/33542150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe1707
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