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Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ
Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the blood‐brain barrier. Genome‐wide association studies have shown variations in the clusterin gene (CLU) to influence t...
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| Publié dans: | Brain Pathol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8029153/ https://ncbi.nlm.nih.gov/pubmed/27248362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12392 |
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