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Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the blood‐brain barrier. Genome‐wide association studies have shown variations in the clusterin gene (CLU) to influence t...

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Podrobná bibliografie
Vydáno v:Brain Pathol
Hlavní autoři: Miners, J. Scott, Clarke, Polly, Love, Seth
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8029153/
https://ncbi.nlm.nih.gov/pubmed/27248362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12392
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