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Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ
Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the blood‐brain barrier. Genome‐wide association studies have shown variations in the clusterin gene (CLU) to influence t...
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| Pubblicato in: | Brain Pathol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8029153/ https://ncbi.nlm.nih.gov/pubmed/27248362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12392 |
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