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Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ
Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the blood‐brain barrier. Genome‐wide association studies have shown variations in the clusterin gene (CLU) to influence t...
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| Publicado no: | Brain Pathol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8029153/ https://ncbi.nlm.nih.gov/pubmed/27248362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12392 |
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