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Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

Clusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the blood‐brain barrier. Genome‐wide association studies have shown variations in the clusterin gene (CLU) to influence t...

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Publicat a:Brain Pathol
Autors principals: Miners, J. Scott, Clarke, Polly, Love, Seth
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8029153/
https://ncbi.nlm.nih.gov/pubmed/27248362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12392
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