Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the peritoneum; therefore, it is crucial to study dise...

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Vydáno v:Cell Death Dis
Hlavní autoři: Russo, Angela, Colina, Jose A., Moy, Junlone, Baligod, Seth, Czarnecki, Austin A., Varughese, Peter, Lantvit, Daniel D., Dean, Matthew J., Burdette, Joanna E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027874/
https://ncbi.nlm.nih.gov/pubmed/33828085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03663-2
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