Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy that is primarily detected at the metastatic stage. Most HGSOC originates from the fallopian tube epithelium (FTE) and metastasizes to the ovary before invading the peritoneum; therefore, it is crucial to study dise...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Russo, Angela, Colina, Jose A., Moy, Junlone, Baligod, Seth, Czarnecki, Austin A., Varughese, Peter, Lantvit, Daniel D., Dean, Matthew J., Burdette, Joanna E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027874/
https://ncbi.nlm.nih.gov/pubmed/33828085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03663-2
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