Inhibition of the I(Na/K) and the activation of peak I(Na) contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs

Aconitine (ACO), a main active ingredient of Aconitum, is well-known for its cardiotoxicity. However, the mechanisms of toxic action of ACO remain unclear. In the current study, we investigated the cardiac effects of ACO and mesaconitine (MACO), a structurally related analog of ACO identified in Aco...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Wang, Xiang-chong, Jia, Qing-zhong, Yu, Yu-lou, Wang, Han-dong, Guo, Hui-cai, Ma, Xin-di, Liu, Chun-tong, Chen, Xue-yan, Miao, Qing-feng, Guan, Bing-cai, Su, Su-wen, Wei, He-ming, Wang, Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027609/
https://ncbi.nlm.nih.gov/pubmed/32747718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-0467-6
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