Macrophages bind LDL using heparan sulfate and the perlecan protein core

The retention of low-density lipoprotein (LDL) is a key process in the pathogenesis of atherosclerosis and largely mediated via smooth-muscle cell-derived extracellular proteoglycans including the glycosaminoglycan chains. Macrophages can also internalize lipids via complexes with proteoglycans. How...

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Gepubliceerd in:J Biol Chem
Hoofdauteurs: Ng, Chun-yi, Whitelock, John M., Williams, Helen, Kim, Ha Na, Medbury, Heather J., Lord, Megan S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027565/
https://ncbi.nlm.nih.gov/pubmed/33684447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100520
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