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Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes. The subendothelial extracellular matrix is a key site for deposition of myeloperoxidase and damage by myeloperoxidase-...

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Detalhes bibliográficos
Main Authors: Rees, Martin D., Whitelock, John M., Malle, Ernst, Chuang, Christine Y., Iozzo, Renato V., Nilasaroya, Anastasia, Davies, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818291/
https://ncbi.nlm.nih.gov/pubmed/19788922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2009.09.005
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