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Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes. The subendothelial extracellular matrix is a key site for deposition of myeloperoxidase and damage by myeloperoxidase-...

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Bibliographische Detailangaben
Hauptverfasser: Rees, Martin D., Whitelock, John M., Malle, Ernst, Chuang, Christine Y., Iozzo, Renato V., Nilasaroya, Anastasia, Davies, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818291/
https://ncbi.nlm.nih.gov/pubmed/19788922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2009.09.005
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