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Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes. The subendothelial extracellular matrix is a key site for deposition of myeloperoxidase and damage by myeloperoxidase-...

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Bibliografski detalji
Glavni autori: Rees, Martin D., Whitelock, John M., Malle, Ernst, Chuang, Christine Y., Iozzo, Renato V., Nilasaroya, Anastasia, Davies, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818291/
https://ncbi.nlm.nih.gov/pubmed/19788922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2009.09.005
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