Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

The potent oxidants hypochlorous acid (HOCl) and hypobromous acid (HOBr) are produced extracellularly by myeloperoxidase, following release of this enzyme from activated leukocytes. The subendothelial extracellular matrix is a key site for deposition of myeloperoxidase and damage by myeloperoxidase-...

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Detaylı Bibliyografya
Asıl Yazarlar: Rees, Martin D., Whitelock, John M., Malle, Ernst, Chuang, Christine Y., Iozzo, Renato V., Nilasaroya, Anastasia, Davies, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818291/
https://ncbi.nlm.nih.gov/pubmed/19788922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2009.09.005
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