Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

Developing efficacious drug delivery systems for targeted cancer chemotherapy remains a major challenge. Here we demonstrated a kind of pH-responsive PEGylated doxorubicin (DOX) prodrug via the effective esterification and Schiff base reactions, which could self-assemble into the biodegradable micel...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Song, Jian, Xu, Bingbing, Yao, Hui, Lu, Xiaofang, Tan, Yang, Wang, Bingyang, Wang, Xing, Yang, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027505/
https://ncbi.nlm.nih.gov/pubmed/33842372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.656717
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