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Design, Synthesis, and Characterization of Schiff Base Bond-Linked pH-Responsive Doxorubicin Prodrug Based on Functionalized mPEG-PCL for Targeted Cancer Therapy

The side effects of doxorubicin (DOX) extremely limit its application in the treatment of malignant tumors. Nano-sized polymeric drugs based on the acidic microenvironment of tissular- or intra- tumor have attracted ample attention because of their potential in reducing side effects. In this researc...

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Detalhes bibliográficos
Publicado no:Polymers (Basel)
Main Authors: Zhai, Yinglei, Zhou, Xing, Zhang, Zhiqiang, Zhang, Lei, Wang, Dianyu, Wang, Xinhui, Sun, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404085/
https://ncbi.nlm.nih.gov/pubmed/30961052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/polym10101127
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