Telomeric Double Strand Breaks in G1 Human Cells Facilitate Formation of 5′ C-Rich Overhangs and Recruitment of TERRA

Telomeres, repetitive nucleoprotein complexes that protect chromosomal termini and prevent them from activating inappropriate DNA damage responses (DDRs), shorten with cell division and thus with aging. Here, we characterized the human cellular response to targeted telomeric double-strand breaks (DS...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Nelson, Christopher B., Alturki, Taghreed M., Luxton, Jared J., Taylor, Lynn E., Maranon, David G., Muraki, Keiko, Murnane, John P., Bailey, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027502/
https://ncbi.nlm.nih.gov/pubmed/33841503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.644803
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