TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal cancer. However, key host factors that may control the generation of the inner mucus layer are rarely reported. Here, we identify a novel function of TRIM34 in goblet cells (GCs) in controlling inner mucus lay...

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Bibliografiset tiedot
Julkaisussa:Cell Mol Immunol
Päätekijät: Lian, Qiaoshi, Yan, Shanshan, Yin, Qi, Yan, Chenghua, Zheng, Wanwei, Gu, Wangpeng, Zhao, Xinhao, Fan, Weiguo, Li, Xuezhen, Ma, Liyan, Ling, Zhiyang, Zhang, Yaguang, Liu, Jie, Li, Jinsong, Sun, Bing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027410/
https://ncbi.nlm.nih.gov/pubmed/32094504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0366-2
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