TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity

Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal cancer. However, key host factors that may control the generation of the inner mucus layer are rarely reported. Here, we identify a novel function of TRIM34 in goblet cells (GCs) in controlling inner mucus lay...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Lian, Qiaoshi, Yan, Shanshan, Yin, Qi, Yan, Chenghua, Zheng, Wanwei, Gu, Wangpeng, Zhao, Xinhao, Fan, Weiguo, Li, Xuezhen, Ma, Liyan, Ling, Zhiyang, Zhang, Yaguang, Liu, Jie, Li, Jinsong, Sun, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027410/
https://ncbi.nlm.nih.gov/pubmed/32094504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-0366-2
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