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Chronic α1-Na/K-ATPase inhibition reverses the elongation of the axon initial segment of the hippocampal CA1 pyramidal neurons in Angelman syndrome model mice

Angelman syndrome (AS) is a neurodevelopmental disorder caused by the loss of function of the maternal UBE3A gene. The hippocampus is one of the most prominently affected brain regions in AS model mice, manifesting in severe hippocampal-dependent memory and plasticity deficits. Previous studies in A...

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發表在:Neuropsychopharmacology
Main Authors: Rayi, Prudhvi Raj, Bagrov, Alexei Y., Kaphzan, Hanoch
格式: Artigo
語言:Inglês
出版: Springer International Publishing 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027375/
https://ncbi.nlm.nih.gov/pubmed/33214655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-020-00907-1
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