First-in-human study of inhaled Azacitidine in patients with advanced non-small cell lung cancer

BACKGROUND: Aerosolized Azacitidine has been shown to inhibit orthotopic lung cancer growth and induce re-expression of methylated tumor suppressor genes in murine models. We hypothesized that inhaled Azacitidine is safe and effective in reversing epigenetic changes in the bronchial epithelium secon...

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Detalhes bibliográficos
Publicado no:Lung Cancer
Main Authors: Cheng, Haiying, Zou, Yiyu, Shah, Chirag D., Fan, Ni, Bhagat, Tushar D., Gucalp, Rasim, Kim, Mimi, Verma, Amit, Piperdi, Bilal, Spivack, Simon D., Halmos, Balazs, Perez-Soler, Roman
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026712/
https://ncbi.nlm.nih.gov/pubmed/33636454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2021.02.015
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