VLA4-nanoparticles hijack cell adhesion mediated drug resistance (CAM-DR) to target refractory myeloma cells and prolong survival

BACKGROUND. In multiple myeloma (MM), drug resistant cells underlie relapse or progression following chemotherapy. Cell adhesion mediated-drug resistance (CAM-DR) is an established mechanism used by MMC to survive chemotherapy and its markers are upregulated in residual disease. The integrin VLA4 (α...

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Pubblicato in:Clin Cancer Res
Autori principali: Fontana, Francesca, Scott, Michael J., Allen, John S., Yang, Xiaoxia, Cui, Grace, Pan, Dipanjan, Yanaba, Noriko, Fiala, Mark A., O’Neal, Julie, Schmieder-Atteberry, Anne H., Ritchey, Julie, Rettig, Michael, Simons, Kathleen, Fletcher, Steven, Vij, Ravi, DiPersio, John F., Lanza, Gregory M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026499/
https://ncbi.nlm.nih.gov/pubmed/33355244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2839
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