BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells

Here we show that interruption of the VCAM-1/VLA-4 axis with a small molecule inhibitor of VLA-4, BIO5192, results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels. An additive affect on HSPC mobilization (3-fold) was observed when plerixaf...

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Detalhes bibliográficos
Main Authors: Ramirez, Pablo, Rettig, Michael P., Uy, Geoffrey L., Deych, Elena, Holt, Matthew S., Ritchey, Julie K., DiPersio, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727418/
https://ncbi.nlm.nih.gov/pubmed/19571319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-184721
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