Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells

Mobilized peripheral blood has become the primary source of hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation, with a 5-day course of granulocyte colony-stimulating factor (G-CSF) as the most common regimen used for HSPC mobilization. The CXCR4 inhibitor plerixafor is a m...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Karpova, Darja, Rettig, Michael P., Ritchey, Julie, Cancilla, Daniel, Christ, Stephanie, Gehrs, Leah, Chendamarai, Ezhilarasi, Evbuomwan, Moses O., Holt, Matthew, Zhang, Jingzhu, Abou-Ezzi, Grazia, Celik, Hamza, Wiercinska, Eliza, Yang, Wei, Gao, Feng, Eissenberg, Linda G., Heier, Richard F., Arnett, Stacy D., Meyers, Marvin J., Prinsen, Michael J., Griggs, David W., Trumpp, Andreas, Ruminski, Peter G., Morrow, Dwight M., Bonig, Halvard B., Link, Daniel C., DiPersio, John F.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597242/
https://ncbi.nlm.nih.gov/pubmed/31085833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124738
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