Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells

Mobilized peripheral blood has become the primary source of hematopoietic stem and progenitor cells (HSPCs) for stem cell transplantation, with a 5-day course of granulocyte colony-stimulating factor (G-CSF) as the most common regimen used for HSPC mobilization. The CXCR4 inhibitor plerixafor is a m...

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Publicado en:J Clin Invest
Main Authors: Karpova, Darja, Rettig, Michael P., Ritchey, Julie, Cancilla, Daniel, Christ, Stephanie, Gehrs, Leah, Chendamarai, Ezhilarasi, Evbuomwan, Moses O., Holt, Matthew, Zhang, Jingzhu, Abou-Ezzi, Grazia, Celik, Hamza, Wiercinska, Eliza, Yang, Wei, Gao, Feng, Eissenberg, Linda G., Heier, Richard F., Arnett, Stacy D., Meyers, Marvin J., Prinsen, Michael J., Griggs, David W., Trumpp, Andreas, Ruminski, Peter G., Morrow, Dwight M., Bonig, Halvard B., Link, Daniel C., DiPersio, John F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597242/
https://ncbi.nlm.nih.gov/pubmed/31085833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124738
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