15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration

The splenic microenvironment regulates hematopoietic stem and progenitor cell (HSPC) function, particularly during demand-adapted hematopoiesis; however, practical strategies to enhance splenic support of transplanted HSPCs have proved elusive. We have previously demonstrated that inhibiting 15-hydr...

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Publicat a:JCI Insight
Autors principals: Smith, Julianne N.P., Dawson, Dawn M., Christo, Kelsey F., Jogasuria, Alvin P., Cameron, Mark J., Antczak, Monika I., Ready, Joseph M., Gerson, Stanton L., Markowitz, Sanford D., Desai, Amar B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026178/
https://ncbi.nlm.nih.gov/pubmed/33600377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143658
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