15-PGDH inhibition activates the splenic niche to promote hematopoietic regeneration

The splenic microenvironment regulates hematopoietic stem and progenitor cell (HSPC) function, particularly during demand-adapted hematopoiesis; however, practical strategies to enhance splenic support of transplanted HSPCs have proved elusive. We have previously demonstrated that inhibiting 15-hydr...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Smith, Julianne N.P., Dawson, Dawn M., Christo, Kelsey F., Jogasuria, Alvin P., Cameron, Mark J., Antczak, Monika I., Ready, Joseph M., Gerson, Stanton L., Markowitz, Sanford D., Desai, Amar B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026178/
https://ncbi.nlm.nih.gov/pubmed/33600377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.143658
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