Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks

Flap endonuclease 1 (FEN1) is a member of the family of structure-specific endonucleases implicated in regulation of DNA damage response and DNA replication. So far, knowledge on the role of FEN1 during viral infections is limited. Previous publications indicated that poxviruses encode a conserved p...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Schilling, Eva-Maria, Scherer, Myriam, Rothemund, Franziska, Stamminger, Thomas
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026080/
https://ncbi.nlm.nih.gov/pubmed/33770148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009460
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